Protein Details: Neuronal acetylcholine receptor subunit alpha-9
Protein ID
ICDB_Pro_1662
Protein Name
Neuronal acetylcholine receptor subunit alpha-9
Gene Name
CHRNA9; NACHRA9
Organism
Homo sapiens (Human)
Length
479 amino acids
AlphaFoldDB
AF-Q9UGM1-F1-model_v4.pdb
Function
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium;the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear;this leads to a reduction in basilar membrane motion;altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. .
Sequence
Ligand Binding
Binding Site
SITE 31: "Involved in the interaction with the conotoxin GeXXA"; /evidence="ECO:0000269|PubMed:26395518"
Disease
Tobacco Addiction
Location
Expressed in the outer hair cells of the cochlea and the neurons of dorsal root ganglia
DOI ID
10.1073/pnas.051622798; 10.1016/s0378-5955(02)00380-5; 10.1016/s0306-4522(02)00274-9; 10.1523/jneurosci.2102-04.2004; 10.1124/mol.65.2.453; 10.1038/srep14261; 10.1124/mol.114.096511; 10.1124/mol.114.096511err
RefSeq
NP_072161.1; XP_017445156.1;